IGF-1 (insulin-like growth factor 1)

IGF-1 is a 70-residue protein with three disulfide bonds; mecasermin is its recombinant form.

IGF-1 testing at Vanguard Laboratory is quoted, with the method agreed per sample.

Compound data

Type

single-chain protein, 70 residues

Formula

C₃₃₁H₅₁₂N₉₄O₁₀₁S₇

Molecular weight

7649 g/mol (average)

CAS number

68562-41-4 (mecasermin)

Structure and names

1 Gly · 2 Pro · 3 Glu · 4 Thr · 5 Leu · 6 Cys · 7 Gly · 8 Ala · 9 Glu · 10 Leu · 11 Val · 12 Asp · 13 Ala · 14 Leu · 15 Gln · 16 Phe · 17 Val · 18 Cys · 19 Gly · 20 Asp · 21 Arg · 22 Gly · 23 Phe · 24 Tyr · 25 Phe · 26 Asn · 27 Lys · 28 Pro · 29 Thr · 30 Gly · 31 Tyr · 32 Gly · 33 Ser · 34 Ser · 35 Ser · 36 Arg · 37 Arg · 38 Ala · 39 Pro · 40 Gln · 41 Thr · 42 Gly · 43 Ile · 44 Val · 45 Asp · 46 Glu · 47 Cys · 48 Cys · 49 Phe · 50 Arg · 51 Ser · 52 Cys · 53 Asp · 54 Leu · 55 Arg · 56 Arg · 57 Leu · 58 Glu · 59 Met · 60 Tyr · 61 Cys · 62 Ala · 63 Pro · 64 Leu · 65 Lys · 66 Pro · 67 Ala · 68 Lys · 69 Ser · 70 Ala

Disulfides: Cys6-Cys48, Cys18-Cys61 and Cys47-Cys52.

Other names: mecasermin, somatomedin C

What's reported

Purity of the protein
Identity, by retention time and intact mass where agreed
Aggregates, where agreed

Tests and prices

Quoted. Send the protein name, the expected mass or sequence and the form for a quote.

Sample amount and turnaround

We confirm the sample amount and turnaround with your quote. Send the material sealed, cold and labeled.

Salts, forms and compendial references

Usually supplied as a lyophilized recombinant protein; tell us the form, the expected mass and any tag or fusion partner.

Questions about IGF-1 testing

Can you tell IGF-1 from IGF-1 LR3?

Yes. IGF-1 LR3 has an extra 13-residue extension and an arginine at position 3, so it is much heavier and separates from IGF-1.

Why is protein testing quoted?

Large proteins need a test plan matched to the protein and the form you send, so it is agreed before the sample is sent.

Sources

Sequence and formula: native human IGF-1 (mecasermin).

Order

Send the product name, the form of the ingredient and the label claim for a quote, or submit a sample with the sample form.

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