Fulvestrant

Fulvestrant: steroidal estrogen receptor antagonist.

Purity and quantity by the chromatographic method matched to the compound (HPLC-UV, LC-MS or GC-MS), with identity against a reference standard. $250 per sample; raw powder purity $200. Results in 3 to 5 business days.

Structure

Fulvestrant: 2D structure drawn from the PubChem record (CID 104741).

Compound data

CAS number

129453-61-8

Formula

C₃₂H₄₇F₅O₃S

Molecular weight

606.8 g/mol (monoisotopic 606.32)

Type

steroidal estrogen receptor antagonist

Structure and names

IUPAC name: (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Other names: ICI 182,780

How Vanguard tests Fulvestrant

Identity, purity and quantity are measured by the chromatographic method matched to the compound (HPLC-UV, LC-MS or GC-MS) against a reference standard, $250 per sample with results in 3 to 5 business days.

Full testing to the USP Fulvestrant monograph is available and quoted: identification by infrared absorption and HPLC, assay by HPLC, and impurities by HPLC.

What's reported

Purity, as percent of total peak area
Quantity, in mg per unit or % w/w against the label
Identity, reported as match or no match against the reference standard

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days.

Salts, forms and compendial references

A USP monograph exists for Fulvestrant. Monograph testing is quoted.
Tell us the salt or form the label states, so quantity is reported on the same basis.
One page covers Fulvestrant and its salts and forms.

Questions about Fulvestrant testing

Fulvestrant shows two peaks. Is that an impurity?

Not necessarily. Fulvestrant is a mixture of two sulfoxide diastereomers, which HPLC can separate; results report each and the total.

What does the purity result include?

The main peak's share of the total peak area by HPLC-UV. Related compounds above the reporting limit show as separate peaks, and LC-MS can identify them on request.

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity against a reference standard. Full testing to the USP Fulvestrant monograph adds the monograph's own tests and is quoted.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/104741

Order

Start an order online, or send the compound name and the tests you need for a quote.

All research compounds