Setipiprant

Setipiprant: prostaglandin D2 receptor (CRTH2) antagonist.

Purity and quantity by the chromatographic method matched to the compound (HPLC-UV, LC-MS or GC-MS), with identity against a reference standard. $250 per sample; raw powder purity $200. Results in 3 to 5 business days.

Structure

Setipiprant: 2D structure drawn from the PubChem record (CID 49843471).

Compound data

CAS number

866460-33-5

Formula

C₂₄H₁₉FN₂O₃

Molecular weight

402.4 g/mol (monoisotopic 402.14)

Type

prostaglandin D2 receptor (CRTH2) antagonist

Structure and names

IUPAC name: 2-[8-fluoro-2-(naphthalene-1-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid

Other names: ACT-129968, KYTH-105

How Vanguard tests Setipiprant

Identity, purity and quantity are measured by the chromatographic method matched to the compound (HPLC-UV, LC-MS or GC-MS) against a reference standard, $250 per sample with results in 3 to 5 business days.

What's reported

Purity, as percent of total peak area
Quantity, in mg per unit or % w/w against the label
Identity, reported as match or no match against the reference standard

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days.

Salts, forms and compendial references

Tell us the salt or form the label states, so quantity is reported on the same basis.
One page covers Setipiprant and its salts and forms.

Questions about Setipiprant testing

Can you confirm setipiprant by mass?

Yes. LC-MS identity checks the measured mass against setipiprant's 402.14 Da monoisotopic mass.

What does the purity result include?

The main peak's share of the total peak area by HPLC-UV. Related compounds above the reporting limit show as separate peaks, and LC-MS can identify them on request.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/49843471

Order

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