Creatine is a guanidino acid. Supplements usually contain creatine monohydrate, and a USP monograph exists for creatine monohydrate.
Creatine testing at Vanguard Laboratory: purity and quantity $250 per sample, with results in 3 to 5 business days.
Creatine: 2D structure drawn from the PubChem record (CID 586).
57-00-1 (creatine)
6020-87-7 (monohydrate)
C4H9N3O2
monohydrate C4H9N3O2·H2O
131.13 g/mol (monoisotopic 131.07)
monohydrate 149.15 g/mol
guanidino acid, dietary ingredient
IUPAC name: 2-[carbamimidoyl(methyl)amino]acetic acid
Other names: N-amidinosarcosine, (alpha-methylguanido)acetic acid
Identity, purity and quantity are measured by a chromatographic assay, with detection selected for the compound, against a creatine reference standard, $250 per sample with results in 3 to 5 business days. Finished products and other creatine forms use the same approach, with sample preparation matched to the product.
Full testing to the USP Creatine Monohydrate monograph is available and quoted: identification by HPLC retention time against the USP Creatine reference standard, assay by HPLC with UV detection, and the related compounds creatinine, dicyandiamide and dihydrotriazine by HPLC.
$250
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the raw material or finished product sealed and labeled, with the label claim and the form of creatine it contains.
If the label states creatine monohydrate and the result is reported as creatine, the water of hydration is not counted. Tell us which basis the label uses and we report on that basis.
Yes. Creatine can convert to creatinine in solution, especially when warm or acidic, so creatinine is the impurity most often checked in liquids, gummies and stored powders.
Yes. Send the product with its label; the sample preparation is matched to the blend.
Send the product name, the form of the ingredient and the label claim for a quote, or submit a sample with the sample form.
