Kanna (mesembrine)

Kanna: Sceletium tortuosum aerial parts.

Kanna testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of a Kanna marker compound

Marker compound: 2D structure drawn from the PubChem record (CID 394162).

Compound data

Botanical source

Sceletium tortuosum aerial parts

Marker compounds

mesembrine and related alkaloids (mesembrenone, mesembrenol)

Basis

total or named markers, as your specification states

Type

botanical ingredient

Structure and names

Marker compounds: mesembrine and related alkaloids (mesembrenone, mesembrenol).

How Vanguard tests Kanna

Kanna is extracted and its marker compounds separated by reversed-phase HPLC with UV detection, with LC-MS identity of the markers where needed. Marker compounds are measured against reference standards, $250 per sample with results in 3 to 5 business days. Tell us the basis your specification uses: a total, named markers or a single compound.

What's reported

  • Marker compounds, as % w/w on the basis your specification states
  • Quantity, in mg per serving or % w/w against the label
  • Identity, reported as match or no match against the reference standard

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Tell us the salt or form the label states, so quantity is reported on the same basis.
  • One page covers Kanna and its salts and forms.

Questions about Kanna testing

Mesembrine or total alkaloids?

HPLC measures mesembrine and the related alkaloids against reference standards, reported individually and as a total.

Can you test it in a finished product?

Yes. Capsules, powders, gummies and liquids are measured with sample preparation matched to the product, and reported in mg per serving or % w/w against the label.

USP monograph: Kanna (Sceletium tortuosum)

The USP Herbal Medicines Compendium monograph (proposed for development) covers identity by HPTLC fingerprint and an assay of marker compounds by HPLC.

Forms and titles: Sceletium tortuosum Aerial Parts

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV measurement of mesembrine-type alkaloids, with LC-MS identity. The USP Herbal Medicines Compendium monograph for Sceletium tortuosum Aerial Parts is still in development; testing against it is available and quoted.

What are the mesembrine alkaloids?

Mesembrine, mesembrenone, mesembrenol and mesembranol are the main alkaloids in kanna, and their ratio varies with plant source and processing. They are measured individually against reference standards.

Does fermented kanna test differently?

Traditional fermentation and drying change the alkaloid ratio, often raising mesembrine relative to mesembrenone. Results are reported for the material as received.

What can be confused with kanna?

The monograph lists Aptenia species as a potential confounding material. The alkaloid profile helps tell genuine Sceletium from look-alike succulents.

Order

Send the product name, the form of the ingredient and the label claim for a quote, or submit a sample with the sample form.