Kava (kavalactones)

Kava: Piper methysticum root.

Kava testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of a Kava marker compound

Marker compound: 2D structure drawn from the PubChem record (CID 5281565).

Compound data

Botanical source

Piper methysticum root

Marker compounds

the six major kavalactones: kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin and desmethoxyyangonin

Basis

total or named markers, as your specification states

Type

botanical ingredient

Structure and names

Marker compounds: the six major kavalactones: kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin and desmethoxyyangonin.

How Vanguard tests Kava

Kava is extracted and its marker compounds separated by reversed-phase HPLC with UV detection, with LC-MS identity of the markers where needed. Marker compounds are measured against reference standards, $250 per sample with results in 3 to 5 business days. Tell us the basis your specification uses: a total, named markers or a single compound.

What's reported

  • Marker compounds, as % w/w on the basis your specification states
  • Quantity, in mg per serving or % w/w against the label
  • Identity, reported as match or no match against the reference standard

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Tell us the salt or form the label states, so quantity is reported on the same basis.
  • One page covers Kava and its salts and forms.

Questions about Kava testing

Total kavalactones or each one?

HPLC measures the six major kavalactones against reference standards, reported individually and as a total.

Can you test it in a finished product?

Yes. Capsules, powders, gummies and liquids are measured with sample preparation matched to the product, and reported in mg per serving or % w/w against the label.

USP monograph: Kava (Piper methysticum)

The USP Herbal Medicines Compendium monograph covers identity by HPTLC fingerprint and content of the six major kavalactones (methysticin, dihydromethysticin, kavain, dihydrokavain, yangonin and desmethoxyyangonin) by HPLC.

Forms and titles: Piper methysticum Root and Rhizome; Piper methysticum Root and Rhizome Powder; Piper methysticum Rootstock; Piper methysticum Rootstock Dry Extract; Piper methysticum Rootstock Powder

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV measurement of six major kavalactones, with LC-MS identity. Full testing to the USP Herbal Medicines Compendium monograph for Piper methysticum Root and Rhizome is available and quoted.

Why are six kavalactones measured?

Kava’s composition is described by six major kavalactones, and the monograph sums all six. Their relative ratio, often called the chemotype, differs between cultivars.

Can kava root be told from stems and leaves?

Stems, leaves and peelings have a different kavalactone pattern and tend to be higher in flavokavains. Comparing the profile with root reference material helps flag these materials.

Is yangonin stable in solution?

Yangonin and desmethoxyyangonin can isomerize under light in solution, so standards and samples are protected from light during analysis.

Order

Send the product name, the form of the ingredient and the label claim for a quote, or submit a sample with the sample form.