Aspirin (acetylsalicylic acid)

Aspirin: salicylate (NSAID).

Aspirin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Aspirin: 2D structure drawn from the PubChem record (CID 2244).

Compound data

CAS number

50-78-2

Formula

C₉H₈O₄

Molecular weight

180.16 g/mol

Type

Salicylate (NSAID)

Structure and names

Identity: Aspirin

IUPAC name: 2-acetyloxybenzoic acid

How Vanguard tests Aspirin

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and a ferric chloride color test, assay by titration, free salicylic acid by colorimetric comparison, loss on drying, readily carbonizable substances, residue on ignition, chloride and sulfate. Full testing to the USP Aspirin monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Aspirin (CAS 50-78-2)
Aspirin Boluses
Buffered Aspirin
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Aspirin testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Aspirin monograph is available and quoted.

Why does free salicylic acid matter?

Aspirin breaks down to salicylic acid and acetic acid when it meets moisture. Free salicylic acid is the main sign of aging, and HPLC measures it separately from aspirin.

My aspirin smells like vinegar. What does that mean?

A vinegar smell comes from acetic acid released as aspirin breaks down. Testing shows how much aspirin remains and how much salicylic acid has formed.

Can buffered or coated aspirin tablets be tested?

Yes. Tablets are ground and dissolved so the result reflects the total aspirin per tablet. Buffering agents and coatings do not interfere with HPLC.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2244

Identity facts from the USP monograph header for this compound.

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