Boldo leaf (Peumus boldus)

Boldo leaf: botanical (leaf).

Boldo leaf testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Marker compound: 2D structure drawn from the PubChem record (CID 10154).

Compound data

Botanical source

Peumus boldus Leaf

Marker compounds

boldine, total alkaloids (as boldine)

Basis

total or named markers, as your specification states

Type

Botanical (leaf)

Structure and names

Marker compounds: boldine (CAS 476-70-0), total alkaloids (as boldine)

How Vanguard tests Boldo leaf

Method for the $250 identity, purity and quantity test: HPLC-UV marker-compound assay (boldine), LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP Herbal Medicines Compendium monograph covers identity by HPTLC fingerprint and content of boldine by HPLC.

What's reported

Marker compounds, as % w/w on the basis your specification states
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Peumus boldus Leaf
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Boldo leaf testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for the marker compound (boldine), and LC-MS for identity. The USP Herbal Medicines Compendium monograph for Peumus boldus leaf is still in development; testing against it is available and quoted.

What is boldine and why is it the marker?

Boldine is the main aporphine alkaloid in boldo leaf. Measuring it gives a check on both identity and strength of the leaf.

Can other leaves be mistaken for boldo?

Yes. The monograph lists Cryptocarya peumus as a look-alike with similar leaves. The alkaloid and HPLC profile help separate true boldo from substitutes.

Does boldo leaf also contain volatile oil?

Yes, boldo leaf has a volatile oil with ascaridole and other terpenes. The standard test focuses on the alkaloid marker; volatile oil profiling by GC can be quoted separately.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/10154

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.

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