Capsaicin

Capsaicin: capsaicinoid (vanilloid).

Capsaicin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Capsaicin: 2D structure drawn from the PubChem record (CID 1548943).

Compound data

CAS number

404-86-4

Formula

C₁₈H₂₇NO₃

Molecular weight

305.41 g/mol

Type

Capsaicinoid (vanilloid)

Structure and names

Identity: Capsaicin

IUPAC name: (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

How Vanguard tests Capsaicin

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by TLC, assay of capsaicin, dihydrocapsaicin and other capsaicinoids by HPLC, melting range, loss on drying, and residue on ignition. Full testing to the USP Capsaicin monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Capsaicin (CAS 404-86-4)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Capsaicin testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Capsaicin monograph is available and quoted.

Does USP capsaicin contain other capsaicinoids?

Yes. Natural-source capsaicin usually contains dihydrocapsaicin and smaller amounts of other capsaicinoids. HPLC reports them separately and as a total.

Can the test detect synthetic nonivamide?

Yes. Nonivamide (PAVA) separates from capsaicin by HPLC and has a different mass, so substitution or blending shows up.

What sample forms can be tested?

Powder, oleoresin, creams and patches can be tested. Creams and patches need an extraction step before HPLC.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/1548943

Identity facts from the USP monograph header for this compound.

Order

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