Celecoxib

Celecoxib: nSAID (COX-2 selective diaryl pyrazole).

Celecoxib testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Celecoxib: 2D structure drawn from the PubChem record (CID 2662).

Compound data

CAS number

169590-42-5

Formula

C₁₇H₁₄F₃N₃O₂S

Molecular weight

381.4 g/mol

Type

NSAID (COX-2 selective diaryl pyrazole)

Structure and names

Identity: Celecoxib

IUPAC name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

How Vanguard tests Celecoxib

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, and residue on ignition and water. Full testing to the USP Celecoxib monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Celecoxib (CAS 169590-42-5)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Celecoxib testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Celecoxib monograph is available and quoted.

What form does celecoxib usually arrive in for testing?

Most samples are powder or capsule contents. Celecoxib is poorly soluble in water, so it is dissolved in organic solvent before HPLC analysis.

Are celecoxib isomers separated in the purity test?

Synthesis can leave positional isomers and other related compounds, which appear as separate peaks from celecoxib in the HPLC purity profile.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2662

Identity facts from the USP monograph header for this compound.

Order

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