Chinese goldthread (Coptis chinensis)

Chinese goldthread: botanical (alkaloid-containing rhizome).

Chinese goldthread testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Marker compound: 2D structure drawn from the PubChem record (CID 2353).

Compound data

Botanical source

Coptis Species Rhizome

Marker compounds

berberine, coptisine, palmatine, epiberberine

Basis

total or named markers, as your specification states

Type

Botanical (alkaloid-containing rhizome)

Structure and names

Marker compounds: berberine (CAS 2086-83-1), coptisine (CAS 3486-66-6), palmatine (CAS 3486-67-7), epiberberine

How Vanguard tests Chinese goldthread

Method for the $250 identity, purity and quantity test: HPLC-UV marker-compound assay (berberine and related protoberberine alkaloids), LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by HPTLC fingerprint and content of total protoberberine alkaloids and berberine by HPLC. Full testing to the USP Coptis Species Rhizome monograph is available and quoted.

What's reported

Marker compounds, as % w/w on the basis your specification states
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Coptis Species Rhizome
Coptis Species Rhizome Powder
Coptis chinensis Rhizome Aqueous Dry Extract Granules
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Chinese goldthread testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV measurement of berberine and related protoberberine alkaloids, with LC-MS identity. Full testing to the USP Coptis Species Rhizome monograph is available and quoted.

Which Coptis species are covered?

The monograph covers rhizome of Coptis chinensis, Coptis deltoidea or Coptis teeta. The species differ in their alkaloid ratios, for example in coptisine and epiberberine levels.

How is berberine reported, as base or salt?

Reference standards are usually berberine chloride, and results are reported as berberine on a dried basis. A label that states berberine HCl needs a salt conversion before comparison.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2353

Identity facts from the USP monograph header for this compound.

Order

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