Chloroquine phosphate

Chloroquine phosphate: 4-Aminoquinoline antimalarial.

Chloroquine phosphate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Chloroquine phosphate: 2D structure drawn from the PubChem record (CID 2719).

Compound data

CAS number

54-05-7

Formula

C₁₈H₂₆ClN₃

Molecular weight

319.87 g/mol

Type

4-Aminoquinoline antimalarial

Structure and names

Identity: Chloroquine

IUPAC name: 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine

How Vanguard tests Chloroquine phosphate

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared and UV spectroscopy, assay by nonaqueous titration, plus residue on ignition, melting range and loss on drying. Full testing to the USP Chloroquine monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Chloroquine (CAS 54-05-7)
Chloroquine Phosphate (CAS 50-63-5)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Chloroquine phosphate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Chloroquine monograph is available and quoted.

The chloroquine monograph has no HPLC impurity test. What does the $250 test add?

The monograph relies on IR, UV and titration. HPLC-UV adds a purity profile that shows related compounds, and LC-MS confirms the identity by mass.

Is my sample chloroquine base or chloroquine phosphate?

Most tablets and powders are chloroquine phosphate, which is much heavier than the base. Tell us which form the label claim refers to so the result is calculated correctly.

Can the test tell chloroquine from hydroxychloroquine?

Yes. Hydroxychloroquine is 16 mass units heavier by LC-MS and elutes at a different HPLC retention time.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2719

Identity facts from the USP monograph header for this compound.

Order

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