Danshen (Salvia miltiorrhiza)

Danshen: botanical (root and rhizome).

Danshen testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Marker compound: 2D structure drawn from the PubChem record (CID 164676).

Compound data

Botanical source

Salvia miltiorrhiza Root and Rhizome

Marker compounds

tanshinone IIA, cryptotanshinone, tanshinone I, salvianolic acid B

Basis

total or named markers, as your specification states

Type

Botanical (root and rhizome)

Structure and names

Marker compounds: tanshinone IIA (CAS 568-72-9), cryptotanshinone (CAS 35825-57-1), tanshinone I (CAS 568-73-0), salvianolic acid B (CAS 121521-90-2)

How Vanguard tests Danshen

Method for the $250 identity, purity and quantity test: HPLC-UV marker-compound assay (tanshinones and salvianolic acid B), LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP Herbal Medicines Compendium monograph covers identity by HPTLC fingerprint and content of tanshinone IIA, cryptotanshinone, tanshinone I and salvianolic acid B by HPLC. Full testing to the USP Herbal Medicines Compendium monograph for Salvia miltiorrhiza Root and Rhizome is available and quoted.

What's reported

Marker compounds, as % w/w on the basis your specification states
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Salvia miltiorrhiza Root and Rhizome
Salvia miltiorrhiza Root and Rhizome Dry Extract
Salvia miltiorrhiza Root and Rhizome Powder
Salvia miltiorrhiza Root and Rhizome Powdered Extract
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Danshen testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV measurement of tanshinones and salvianolic acid B, with LC-MS identity. Full testing to the USP Herbal Medicines Compendium monograph for Salvia miltiorrhiza Root and Rhizome is available and quoted.

Why are two classes of markers measured?

Danshen contains fat-soluble tanshinones and water-soluble salvianolic acids. Water or ethanol extraction enriches one class over the other, so both are measured to show what the product contains.

Are danshen markers light or heat sensitive?

Tanshinones and salvianolic acid B degrade with light, heat and moisture. Samples are kept cool and protected from light before analysis.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/164676

Identity facts from the USP monograph header for this compound.

Order

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