Dextromethorphan

Dextromethorphan: morphinan antitussive.

Dextromethorphan testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Dextromethorphan: 2D structure drawn from the PubChem record (CID 5360696).

Compound data

CAS number

125-71-3

Formula

C₁₈H₂₅NO

Molecular weight

271.40 g/mol

Type

Morphinan antitussive

Structure and names

Identity: Dextromethorphan

IUPAC name: (1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene

How Vanguard tests Dextromethorphan

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and a chiral HPLC check for levomethorphan, assay by titration, phenolic compounds and N,N-dimethylaniline by color tests, plus residue on ignition and water content. Full testing to the USP Dextromethorphan monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Dextromethorphan (CAS 125-71-3)
Dextromethorphan Hydrobromide
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Dextromethorphan testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Dextromethorphan monograph is available and quoted.

Can LC-MS tell dextromethorphan from levomethorphan?

No. They are mirror-image forms with the same mass and the same retention time on a standard column. The monograph uses a chiral HPLC method to check for levomethorphan, which is quoted separately.

Is my sample the free base or the hydrobromide?

Most syrups, capsules and tablets use dextromethorphan hydrobromide, which is heavier than the base. Tell us which form the label claim refers to so the result is calculated correctly.

Can cough syrups with several actives be tested?

Yes. HPLC separates dextromethorphan from the other actives and flavorings, and the result is reported as dextromethorphan per volume or as percent of label claim.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/5360696

Identity facts from the USP monograph header for this compound.

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