Eprinomectin

Eprinomectin: avermectin macrocyclic lactone (veterinary antiparasitic).

Eprinomectin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of Eprinomectin

Eprinomectin: 2D structure drawn from the PubChem record (CID 6450531).

Compound data

CAS number

123997-26-2

Formula

C50H75NO14

Molecular weight

914.1 g/mol

Type

Avermectin macrocyclic lactone (veterinary antiparasitic)

Structure and names

Identity: Eprinomectin (B1a component)

IUPAC name: N-[(2S,3R,4R,6S)-6-[(2S,3R,4S,6R)-6-[(1’R,2R,3S,4’S,6S,8’R,10’Z,12’S,13’S,14’Z,16’Z,20’R,21’R,24’S)-21′,24′-dihydroxy-3,11′,13′,22′-tetramethyl-2′-oxo-2-propan-2-ylspiro[2,3-dihydropyran-6,6′-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-12′-yl]oxy-4-methoxy-2-methyloxan-3-yl]oxy-4-methoxy-2-methyloxan-3-yl]acetamide

How Vanguard tests Eprinomectin

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, the 8a-oxo-B degradant and organic impurities by HPLC, plus residue on ignition, optical rotation and water content. Full testing to the USP Eprinomectin monograph is available and quoted.

What's reported

  • Purity, as percent of total peak area
  • Quantity, against the label claim
  • Identity, reported as match or no match against the reference standard
  • With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Eprinomectin (CAS 123997-26-2)
  • Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Eprinomectin testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Eprinomectin monograph is available and quoted.

Why does eprinomectin have two components?

Eprinomectin is a mixture of a major B1a component and a minor B1b component that differ by one methylene group. The HPLC assay measures both, and the monograph defines eprinomectin as their sum.

What is 8a-oxo-B?

It is an oxidation product of eprinomectin, so the monograph sets its own HPLC limit for it. A high result usually points to an old or poorly stored sample.

What sample forms are usually tested?

Powder, pour-on solutions and injectable solutions. Each is diluted in an organic solvent and assayed against an eprinomectin reference standard.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/6450531

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.