Octinoxate (octyl methoxycinnamate)

Octinoxate: sunscreen UV filter (cinnamate ester).

Octinoxate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Octinoxate: 2D structure drawn from the PubChem record (CID 5355130).

Compound data

CAS number

5466-77-3

Formula

C₁₈H₂₆O₃

Molecular weight

290.40 g/mol

Type

Sunscreen UV filter (cinnamate ester)

Structure and names

Identity: Octinoxate

IUPAC name: 2-ethylhexyl (E)-3-(4-methoxyphenyl)prop-2-enoate

How Vanguard tests Octinoxate

Method for the $250 identity, purity and quantity test: GC-FID assay and purity, GC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and GC retention time, assay by GC, organic impurities by GC, specific gravity, refractive index and acidity by titration. Full testing to the USP Octinoxate monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Octinoxate (CAS 5466-77-3)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Octinoxate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by GC-FID for assay and purity, and GC-MS for identity. Full testing to the USP Octinoxate monograph is available and quoted.

Why is octinoxate tested by GC?

Octinoxate is an oily ester that vaporizes cleanly, and the USP uses GC for both assay and impurities. GC-MS gives identity from the mass spectrum.

Does octinoxate change in light?

Sunlight converts the normal trans form into the cis isomer, which can appear as a separate peak. Samples should be kept dark before testing.

Can octinoxate be measured in a finished sunscreen?

Yes, after extraction from the cream or lotion. HPLC-UV is often better for finished products with several UV filters, so tell us what else is in the formula.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/5355130

Identity facts from the USP monograph header for this compound.

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