Papaverine hydrochloride

Papaverine hydrochloride: benzylisoquinoline alkaloid.

Papaverine hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Papaverine hydrochloride: 2D structure drawn from the PubChem record (CID 6084).

Compound data

CAS number

61-25-6

Formula

C₂₀H₂₁NO₄ · HCl

Molecular weight

375.85 g/mol

Type

Benzylisoquinoline alkaloid

Structure and names

Identity: Papaverine hydrochloride

IUPAC name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline;hydrochloride

How Vanguard tests Papaverine hydrochloride

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared and UV spectroscopy and a chloride test, assay by nonaqueous titration, a color test for related impurities, and pH, loss on drying and residue on ignition. Full testing to the USP Papaverine Hydrochloride monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Papaverine Hydrochloride (CAS 61-25-6)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Papaverine hydrochloride testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Papaverine Hydrochloride monograph is available and quoted.

Why add LC-MS identity when the monograph uses IR and UV?

IR and UV confirm the overall structure, while LC-MS gives the molecular mass and separates papaverine from other alkaloids, such as noscapine, that can occur in natural-source material.

Is papaverine often found in mixtures?

Yes, it often appears in compounded injectable mixtures with phentolamine and alprostadil. Each labeled compound can be quantified, and mixtures are quoted by the number of compounds.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/6084

Identity facts from the USP monograph header for this compound.

Order

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