Sennosides: botanical extract (anthraquinone glycosides).
Sennosides testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Marker compound: 2D structure drawn from the PubChem record (CID 73111).
Sennosides
sennoside A, sennoside B
total or named markers, as your specification states
Botanical extract (anthraquinone glycosides)
Marker compounds: sennoside A (CAS 81-27-6), sennoside B (CAS 128-57-4)
Method for the $250 identity, purity and quantity test: HPLC-UV marker-compound assay (sennosides A and B), LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by TLC, total sennosides by fluorescence spectroscopy, sennosides A and B by HPLC, plus pH, residue on ignition and loss on drying. Full testing to the USP Sennosides monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC with UV detection for the marker compounds (sennosides A and B), and LC-MS for identity. Full testing to the USP Sennosides monograph is available and quoted.
It is a partly purified mix of anthraquinone glucosides from senna leaf or pod, supplied as calcium salts. Sennosides A and B are the main named components.
Sennosides A and B are the two main glycosides and have reference standards, so they can be measured directly by HPLC. Products often label total sennosides, which the monograph measures by a separate method.
Sennosides can hydrolyze and oxidize to aglycones such as sennidins and rhein-type compounds, especially in moist or warm storage. Lower sennoside values in an older product can reflect this.
https://pubchem.ncbi.nlm.nih.gov/compound/73111
Identity facts from the USP monograph header for this compound.
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