Sertraline hydrochloride: selective serotonin reuptake inhibitor (SSRI).
Sertraline hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Sertraline hydrochloride: 2D structure drawn from the PubChem record (CID 63009).
79559-97-0
C17H17Cl2N · HCl
342.69 g/mol
Selective serotonin reuptake inhibitor (SSRI)
Identity: Sertraline hydrochloride
IUPAC name: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a chloride test, assay by HPLC, the (R,R) isomer and mandelic acid by HPLC, organic impurities by HPLC and gas chromatography, plus residue on ignition and water content. Full testing to the USP Sertraline Hydrochloride monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay and LC-MS for identity. Full testing to the USP Sertraline Hydrochloride monograph is available and quoted.
Sertraline is a single cis (1S,4S) isomer, and its enantiomer and trans isomers can carry through from synthesis. They have the same mass, so a chiral or isomer-selective HPLC method is needed to measure them, which is quoted separately from the $250 test.
Mandelic acid is used to resolve the isomers during manufacture, so the monograph sets a limit for any that remains in the finished salt.
Most samples arrive as powder or tablets. Tablets are ground and extracted, and the result is reported as sertraline hydrochloride or as percent of label claim.
https://pubchem.ncbi.nlm.nih.gov/compound/63009
Identity facts from the USP monograph header for this compound.
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