Alfuzosin hydrochloride

Alfuzosin hydrochloride: alpha-1 adrenergic blocker (quinazoline).

Alfuzosin hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Alfuzosin hydrochloride: 2D structure drawn from the PubChem record (CID 71764).

Compound data

CAS number

81403-68-1

Formula

C₁₉H₂₇N₅O₄ · HCl

Molecular weight

425.91 g/mol

Type

Alpha-1 adrenergic blocker (quinazoline)

Structure and names

Identity: Alfuzosin hydrochloride

IUPAC name: N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide;hydrochloride

How Vanguard tests Alfuzosin hydrochloride

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, a chloride test and HPLC retention time, assay by HPLC, organic impurities by HPLC, and residue on ignition, optical rotation, water and pH. Full testing to the USP Alfuzosin Hydrochloride monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Alfuzosin Hydrochloride (CAS 81403-68-1)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Alfuzosin hydrochloride testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Alfuzosin Hydrochloride monograph is available and quoted.

Is the result reported as the salt or the free base?

The USP material is the hydrochloride, and the assay is reported on that basis unless you ask for free base. The conversion is a fixed ratio of molecular weights.

Does alfuzosin look like other quinazoline compounds?

Alfuzosin shares the 4-amino-6,7-dimethoxyquinazoline core with prazosin, terazosin and doxazosin. They differ in mass and retention time, so LC-MS and HPLC tell them apart.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/71764

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.

All research compounds