Aminophylline: xanthine (theophylline ethylenediamine salt).
Aminophylline testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Aminophylline: 2D structure drawn from the PubChem record (CID 9433).
317-34-0
C16H24N10O4
420.43 g/mol
Xanthine (theophylline ethylenediamine salt)
Identity: Aminophylline (anhydrous)
IUPAC name: bis(1,3-dimethyl-7H-purine-2,6-dione);ethane-1,2-diamine
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a precipitation test with melting point, assay by HPLC, organic impurities by HPLC, and residue on ignition and water. Full testing to the USP Aminophylline monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Aminophylline monograph is available and quoted.
Aminophylline is theophylline paired with ethylenediamine in a two to one ratio. The HPLC result is usually reported as theophylline content, since that is the part with UV absorbance.
It slowly loses ethylenediamine and absorbs carbon dioxide from the air, which can leave free theophylline and a yellowed powder. Tightly sealed samples give the most consistent results.
Yes. The anhydrous and dihydrate forms differ in weight, so the same powder reads differently depending on the basis. Tell us which form is on the label.
https://pubchem.ncbi.nlm.nih.gov/compound/9433
Identity facts from the USP monograph header for this compound.
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