Amoxicillin: beta-lactam antibiotic (aminopenicillin).
Amoxicillin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Amoxicillin: 2D structure drawn from the PubChem record (CID 62883).
61336-70-7
C16H19N3O5S · 3H2O
419.45 g/mol
Beta-lactam antibiotic (aminopenicillin)
Identity: Amoxicillin trihydrate
IUPAC name: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;trihydrate
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monographs cover identity by infrared spectroscopy, HPLC retention time and thin-layer chromatography, assay by HPLC, organic impurities by HPLC, a dimethylaniline limit test, pH, water content, sterility, and bacterial endotoxins. Full testing to the USP Amoxicillin monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Amoxicillin monograph is available and quoted.
Amoxicillin is normally the trihydrate, which is roughly 13% water by weight. The USP assay is on the anhydrous basis, so the water result is needed to compare potency with a label.
Yes. The beta-lactam ring opens in water to form amoxicillin penicilloic acid and related products, and dimers can form in concentrated solutions. Samples are prepared fresh and analyzed promptly so degradation does not skew the result.
Yes. Boluses are ground, extracted and assayed for amoxicillin against a reference standard by HPLC.
https://pubchem.ncbi.nlm.nih.gov/compound/62883
Identity facts from the USP monograph header for this compound.
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