Atracurium besylate: neuromuscular blocking agent (benzylisoquinolinium).
Atracurium besylate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Atracurium besylate: 2D structure drawn from the PubChem record (CID 47320).
64228-81-5
C65H82N2O18S2
1243.48 g/mol
Neuromuscular blocking agent (benzylisoquinolinium)
Identity: Atracurium besylate
IUPAC name: benzenesulfonate;5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, related compounds by HPLC, residue on ignition and water content. Full testing to the USP Atracurium Besylate monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Atracurium Besylate monograph is available and quoted.
Atracurium besylate is a mixture of stereoisomers, and they partly separate into a group of closely related peaks. The isomer group is treated as the main component, and other compounds are reported separately.
Yes. It degrades at room temperature and at higher pH, and laudanosine is one of the main breakdown products. Samples should be shipped cold, and laudanosine shows up in the purity profile if it has formed.
LC-MS confirms the atracurium cation by its mass. Benzenesulfonate is the counter-ion and is accounted for in the quantity calculation when the label states the besylate salt.
https://pubchem.ncbi.nlm.nih.gov/compound/47320
Identity facts from the USP monograph header for this compound.
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