Atropine sulfate: muscarinic antagonist (tropane alkaloid).
Atropine sulfate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Atropine sulfate: 2D structure drawn from the PubChem record (CID 174174).
51-55-8
C17H23NO3
289.37 g/mol
Muscarinic antagonist (tropane alkaloid)
Identity: Atropine
IUPAC name: [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.
The USP Atropine monograph covers identity by infrared spectroscopy and a gold chloride precipitation test, assay by nonaqueous titration with perchloric acid, foreign alkaloids by thin-layer chromatography, residue on ignition, readily carbonizable substances, optical rotation, melting range, and water content. Full testing to the USP Atropine or Atropine Sulfate monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Atropine or Atropine Sulfate monograph is available and quoted.
No. Atropine is the racemate of hyoscyamine. A standard HPLC test reports total atropine, and telling the enantiomers apart needs a chiral method or optical rotation.
Atropine hydrolyzes to tropine and tropic acid and can dehydrate to apoatropine. These separate by HPLC and differ in mass.
Samples are usually atropine sulfate, as powder or solution. The free base is about 83 percent of the sulfate monohydrate weight, and the report states which basis is used.
https://pubchem.ncbi.nlm.nih.gov/compound/174174
Identity facts from the USP monograph header for this compound.
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