Bismuth citrate

Bismuth citrate: mineral salt (bismuth).

Bismuth citrate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Bismuth citrate: 2D structure drawn from the PubChem record (CID 13135).

Compound data

CAS number

813-93-4

Formula

BiC₆H₅O₇

Molecular weight

398.08 g/mol

Type

Mineral salt (bismuth)

Structure and names

Identity: Bismuth citrate

IUPAC name: bismuth 2-hydroxypropane-1,2,3-tricarboxylate

How Vanguard tests Bismuth citrate

Method for the $250 identity, purity and quantity test: ICP-MS metal content, chromatographic assay of the citrate counter-ion, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and chemical tests, assay by complexometric EDTA titration, an arsenic limit, copper, lead, silver and soluble bismuth by atomic absorption, and a nitrate limit test. Full testing to the USP Bismuth Citrate monograph is available and quoted.

What's reported

Metal content by ICP-MS, against the label or specification
Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Bismuth Citrate (CAS 813-93-4)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Bismuth citrate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by ICP-MS for bismuth content and a chromatographic method suited to the compound for the citrate part. Full testing to the USP Bismuth Citrate monograph is available and quoted.

Why does bismuth citrate need two kinds of test?

ICP-MS measures the bismuth and HPLC measures the citrate. Together they show whether the salt matches its expected makeup.

Can the test check for other metals such as lead, silver or copper?

Yes. Other metals can be added to the ICP-MS run on request.

Why is citrate harder to measure than many organic compounds?

Citrate has no aromatic ring and absorbs UV light only weakly at low wavelength, so the lab uses a detection method suited to the compound.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/13135

Identity facts from the USP monograph header for this compound.

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