Bismuth subsalicylate

Bismuth subsalicylate: mineral salt (bismuth).

Bismuth subsalicylate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Bismuth subsalicylate: 2D structure drawn from the PubChem record (CID 53629521).

Compound data

CAS number

14882-18-9

Formula

C₇H₅BiO₄

Molecular weight

362.09 g/mol

Type

Mineral salt (bismuth)

Structure and names

Identity: Bismuth subsalicylate

IUPAC name: bismuth;2-oxidobenzoate;hydroxide

How Vanguard tests Bismuth subsalicylate

Method for the $250 identity, purity and quantity test: ICP-MS metal content, HPLC assay of the salicylate counter-ion, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and a bismuth test, assay of bismuth by EDTA titration and of total salicylates by visible spectrophotometry, an arsenic limit, copper, lead, silver and soluble bismuth by atomic absorption, a nitrate limit, free salicylic acid by HPLC, pH, and loss on drying. Full testing to the USP Bismuth Subsalicylate monograph is available and quoted.

What's reported

Metal content by ICP-MS, against the label or specification
Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Bismuth Subsalicylate (CAS 14882-18-9)
Bismuth Subsalicylate Magma
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Bismuth subsalicylate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by ICP-MS for bismuth content and HPLC for the salicylate part. Full testing to the USP Bismuth Subsalicylate monograph is available and quoted.

Why is salicylate measured as well as bismuth?

Bismuth subsalicylate is defined by both parts, and free salicylic acid is a common impurity. HPLC measures the salicylate and can show free salicylic acid, and ICP-MS measures the bismuth.

Can liquid suspensions be tested?

Yes. Suspensions such as the magma are mixed well and sampled by weight, and the result is reported per milliliter.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/53629521

Identity facts from the USP monograph header for this compound.

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