Calcipotriene: vitamin D3 analog.
Calcipotriene testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Calcipotriene: 2D structure drawn from the PubChem record (CID 5288783).
112965-21-6
C27H40O3
412.60 g/mol
Vitamin D3 analog
Identity: Calcipotriene (anhydrous)
IUPAC name: trans-(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC and by thin-layer chromatography, loss on drying by thermal analysis for the anhydrous form and water determination for the monohydrate. Full testing to the USP Calcipotriene monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC with UV detection for purity and assay, and LC-MS for identity. Full testing to the USP Calcipotriene monograph is available and quoted.
Like other vitamin D compounds, it converts to pre-calcipotriene and other isomers with heat and light. Samples should be kept cool and dark, and these isomers show in the purity profile.
Yes. Calcipotriene is the US name and calcipotriol the international name. It is also supplied as a monohydrate, which assays slightly lower on an as-is basis.
Yes. Topical products contain calcipotriene at very low levels, so a larger sample is extracted and the result is reported per gram of product.
https://pubchem.ncbi.nlm.nih.gov/compound/5288783
Identity facts from the USP monograph header for this compound.
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