Carbamazepine

Carbamazepine: anticonvulsant (dibenzazepine carboxamide).

Carbamazepine testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Carbamazepine: 2D structure drawn from the PubChem record (CID 2554).

Compound data

CAS number

298-46-4

Formula

C₁₅H₁₂N₂O

Molecular weight

236.27 g/mol

Type

Anticonvulsant (dibenzazepine carboxamide)

Structure and names

Identity: Carbamazepine

IUPAC name: benzo[b][1]benzazepine-11-carboxamide

How Vanguard tests Carbamazepine

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, and chloride and sulfate, residue on ignition, acidity, alkalinity and loss on drying. Full testing to the USP Carbamazepine monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Carbamazepine (CAS 298-46-4)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Carbamazepine testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Carbamazepine monograph is available and quoted.

Which impurities show up in carbamazepine purity testing?

The USP monograph names 10,11-dihydrocarbamazepine and iminostilbene as related compounds. Both appear as separate peaks from carbamazepine in the HPLC purity profile.

Does carbamazepine have more than one crystal form?

Yes. Carbamazepine has several anhydrous polymorphs and forms a dihydrate on contact with water. The $250 test reports chemical identity, purity and quantity and does not determine crystal form.

What forms does carbamazepine arrive in?

Usually white to off-white powder, tablets, extended-release tablets or oral suspension. Extended-release tablets and suspensions need their own extraction, so tell us the form when you submit.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2554

Identity facts from the USP monograph header for this compound.

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