Carboplatin: platinum coordination compound (anticancer).
Carboplatin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Carboplatin: 2D structure drawn from the PubChem record (CID 426756).
41575-94-4
C6H12N2O4Pt
371.25 g/mol
Platinum coordination compound (anticancer)
Identity: Carboplatin
IUPAC name: azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, 1,1-cyclobutanedicarboxylic acid and other organic impurities by HPLC, and pH, loss on drying, transmittance and water-insoluble matter. Full testing to the USP Carboplatin monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Carboplatin monograph is available and quoted.
Yes. Platinum can be measured by ICP-MS as a separate quoted test, which complements the HPLC assay of the intact carboplatin molecule.
Carboplatin can exchange its ligand with chloride, so solutions in saline can slowly form other platinum species. Samples are prepared in water or a chloride-free diluent so the result reflects the material as received.
1,1-Cyclobutanedicarboxylic acid, the free ligand released when carboplatin breaks down, is tested on its own by HPLC along with other related compounds.
https://pubchem.ncbi.nlm.nih.gov/compound/426756
Identity facts from the USP monograph header for this compound.
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