Cefmetazole (cefmetazole sodium)

Cefmetazole: cephamycin antibiotic (second generation).

Cefmetazole testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Cefmetazole: 2D structure drawn from the PubChem record (CID 42008).

Compound data

CAS number

56796-20-4

Formula

C₁₅H₁₇N₇O₅S₃

Molecular weight

471.53 g/mol

Type

Cephamycin antibiotic (second generation)

Structure and names

Identity: Cefmetazole

IUPAC name: (6R,7S)-7-[[2-(cyanomethylsulfanyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

How Vanguard tests Cefmetazole

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC with UV at 214 nm, and water determination. Full testing to the USP Cefmetazole monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Cefmetazole (CAS 56796-20-4)
Cefmetazole Sodium
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Cefmetazole testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cefmetazole monograph is available and quoted.

What breaks off cefmetazole as it degrades?

Cefmetazole carries a 1-methyltetrazole-5-thiol side chain that can be released as the molecule breaks down. This and opened beta-lactam products appear as separate peaks in the HPLC profile.

Is cefmetazole reported as the free acid or the sodium salt?

USP expresses cefmetazole content on the anhydrous free acid basis, while vials usually contain the sodium salt. Tell us which basis you need.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/42008

Identity facts from the USP monograph header for this compound.

Order

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