Ceftazidime

Ceftazidime: cephalosporin antibiotic (third generation).

Ceftazidime testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Ceftazidime: 2D structure drawn from the PubChem record (CID 6536864).

Compound data

CAS number

78439-06-2

Formula

C₂₂H₂₂N₆O₇S₂ · 5H₂O

Molecular weight

636.65 g/mol

Type

Cephalosporin antibiotic (third generation)

Structure and names

Identity: Ceftazidime (pentahydrate)

IUPAC name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrate

How Vanguard tests Ceftazidime

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by HPLC, assay by HPLC, and pH, loss on drying, sterility and bacterial endotoxins. Full testing to the USP Ceftazidime monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Ceftazidime (CAS 78439-06-2)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Ceftazidime testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Ceftazidime monograph is available and quoted.

What does ceftazidime release as it degrades?

Ceftazidime releases pyridine from its side chain as it breaks down in solution. Pyridine and opened beta-lactam products appear as separate peaks, so samples are prepared fresh.

Is ceftazidime reported as the pentahydrate?

Ceftazidime is supplied as the pentahydrate, and USP expresses content on the anhydrous basis. Water content links the two.

Why do some ceftazidime vials fizz when dissolved?

Many ceftazidime products contain sodium carbonate, which releases carbon dioxide on reconstitution. Results are still reported as ceftazidime, but the carbonate affects how the sample is prepared.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/6536864

Identity facts from the USP monograph header for this compound.

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