Dapsone

Dapsone: sulfone antibacterial.

Dapsone testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Dapsone: 2D structure drawn from the PubChem record (CID 2955).

Compound data

CAS number

80-08-0

Formula

C₁₂H₁₂N₂O₂S

Molecular weight

248.30 g/mol

Type

Sulfone antibacterial

Structure and names

Identity: Dapsone

IUPAC name: 4-(4-aminophenyl)sulfonylaniline

How Vanguard tests Dapsone

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by thin-layer chromatography, a selenium limit test, and loss on drying. Full testing to the USP Dapsone monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Dapsone (CAS 80-08-0)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Dapsone testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Dapsone monograph is available and quoted.

Why does the USP monograph include a selenium test?

The monograph sets a selenium limit as a check on a process-related contaminant. Selenium is an element, so it is measured by ICP-MS, which is quoted separately from the $250 test.

Is dapsone light sensitive?

Dapsone discolors on exposure to light. Samples should be kept in the dark, and any degradation shows up as extra peaks in the purity profile.

Can dapsone gel be tested?

Yes. Gels are dispersed and extracted before HPLC, and the gel base is checked so it does not interfere with the dapsone peak.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2955

Identity facts from the USP monograph header for this compound.

Order

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