Hydroxyurea: antimetabolite (ribonucleotide reductase inhibitor).
Hydroxyurea testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Hydroxyurea: 2D structure drawn from the PubChem record (CID 3657).
127-07-1
CH4N2O2
76.05 g/mol
Antimetabolite (ribonucleotide reductase inhibitor)
Identity: Hydroxyurea
IUPAC name: hydroxyurea
Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, assay by HPLC, impurities by paper chromatography, loss on drying, and residue on ignition. Full testing to the USP Hydroxyurea monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Hydroxyurea monograph is available and quoted.
Hydroxyurea is very small and polar and has almost no UV absorbance above about 210 nm, so the lab uses a detection method suited to the compound.
Urea is the main related compound and comes from both synthesis and breakdown. Hydroxyurea also degrades with heat and moisture, so samples should be kept dry and cool.
https://pubchem.ncbi.nlm.nih.gov/compound/3657
Identity facts from the USP monograph header for this compound.
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