Losartan potassium: angiotensin II receptor blocker (sartan).
Losartan potassium testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Losartan potassium: 2D structure drawn from the PubChem record (CID 11751549).
124750-99-8
C22H22ClKN6O
461.00 g/mol
Angiotensin II receptor blocker (sartan)
Identity: Losartan potassium
IUPAC name: potassium [2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a potassium test, assay by HPLC, organic impurities by HPLC, and water content. Full testing to the USP Losartan Potassium monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Losartan Potassium monograph is available and quoted.
No. Trace nitrosamines such as NDMA and NDEA, which can occur in sartans from some synthesis routes, need a dedicated LC-MS/MS or GC-MS method. That testing is quoted separately.
Sartans share a biphenyl tetrazole core, but each has its own mass and retention time. LC-MS identity confirms which sartan is present.
Losartan is supplied as the potassium salt and labels usually state losartan potassium, so results are reported on that basis unless another basis is requested.
https://pubchem.ncbi.nlm.nih.gov/compound/11751549
Identity facts from the USP monograph header for this compound.
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