Mercaptopurine: purine analog antimetabolite (thiopurine).
Mercaptopurine testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Mercaptopurine: 2D structure drawn from the PubChem record (CID 667490).
50-44-2
C5H4N4S
152.18 g/mol
Purine analog antimetabolite (thiopurine)
Identity: Mercaptopurine (anhydrous)
IUPAC name: 3,7-dihydropurine-6-thione
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, a phosphorus limit by UV-visible spectrophotometry, and water content by titration. Full testing to the USP Mercaptopurine monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Mercaptopurine monograph is available and quoted.
Mercaptopurine is usually supplied as the monohydrate, and the USP assay is calculated on the anhydrous basis. Water content is needed to compare a result to label.
Yes. Azathioprine is a nitroimidazole derivative of mercaptopurine and thioguanine carries an extra amino group, so all three differ in retention time and mass by LC-MS.
Yes. The thiol group can oxidize to disulfides and to 6-thiouric acid type products, which appear as extra peaks in the purity profile.
https://pubchem.ncbi.nlm.nih.gov/compound/667490
Identity facts from the USP monograph header for this compound.
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