Pilocarpine hydrochloride: muscarinic agonist (imidazole alkaloid).
Pilocarpine hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Pilocarpine hydrochloride: 2D structure drawn from the PubChem record (CID 5910).
92-13-7
C11H16N2O2
208.26 g/mol
Muscarinic agonist (imidazole alkaloid)
Identity: Pilocarpine
IUPAC name: (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared and UV spectroscopy, assay by HPLC, related compounds including isopilocarpine by HPLC, specific rotation, refractive index, water content, chloride and sulfate limit tests, and a colorimetric nitrate limit. Full testing to the USP Pilocarpine, Pilocarpine Hydrochloride or Pilocarpine Nitrate monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Pilocarpine, Pilocarpine Hydrochloride or Pilocarpine Nitrate monograph is available and quoted.
Yes. Isopilocarpine is the epimer of pilocarpine and has the same mass, so it is separated and measured by HPLC. It forms in solution, especially at basic pH and with heat.
It is the ring-opened hydrolysis product of pilocarpine. It separates by HPLC and has a different mass, so it shows up in the purity profile.
Samples are usually the hydrochloride or nitrate salt, often as eye drops. The result is reported for the form named on the label.
https://pubchem.ncbi.nlm.nih.gov/compound/5910
Identity facts from the USP monograph header for this compound.
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