Ribavirin: antiviral nucleoside analog.
Ribavirin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Ribavirin: 2D structure drawn from the PubChem record (CID 37542).
36791-04-5
C8H12N4O5
244.20 g/mol
Antiviral nucleoside analog
Identity: Ribavirin
IUPAC name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and thin-layer chromatography, assay by HPLC, organic impurities by HPLC, residue on ignition, optical rotation, pH, and loss on drying. Full testing to the USP Ribavirin monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Ribavirin monograph is available and quoted.
Ribavirin is very polar and elutes early on standard reversed-phase columns. Methods use highly aqueous or polar-retentive conditions so it separates from the solvent front and from its impurities.
Typical impurities include the triazole carboxamide base and the carboxylic acid formed when the amide hydrolyzes. Both separate from ribavirin by HPLC and differ in mass.
https://pubchem.ncbi.nlm.nih.gov/compound/37542
Identity facts from the USP monograph header for this compound.
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