Theophylline: methylxanthine.
Theophylline testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Theophylline: 2D structure drawn from the PubChem record (CID 2153).
58-55-9
C7H8N4O2
180.17 g/mol
Methylxanthine
Identity: Theophylline (anhydrous)
IUPAC name: 1,3-dimethyl-7H-purine-2,6-dione
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP Theophylline monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, residue on ignition, and loss on drying. Full testing to the USP Theophylline or Theophylline Sodium Glycinate monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Theophylline or Theophylline Sodium Glycinate monograph is available and quoted.
Yes. Theophylline and theobromine are isomers with the same mass, so they are told apart by HPLC retention time. Caffeine has an extra methyl group and also differs in mass.
Theophylline is sold both ways, and the monohydrate holds about 9 percent water. The assay basis is stated on the report so it can be compared to label.
It is a mixture of theophylline sodium and glycine. Theophylline is measured by HPLC, and the glycine content is a separate test in full monograph testing.
https://pubchem.ncbi.nlm.nih.gov/compound/2153
Identity facts from the USP monograph header for this compound.
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