Trientine hydrochloride

Trientine hydrochloride: copper chelating agent (polyamine).

Trientine hydrochloride testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of Trientine hydrochloride

Trientine hydrochloride: 2D structure drawn from the PubChem record (CID 71433).

Compound data

CAS number

38260-01-4

Formula

C6H18N4 · 2HCl

Molecular weight

219.16 g/mol

Type

Copper chelating agent (polyamine)

Structure and names

Identity: Trientine hydrochloride

IUPAC name: N’-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;dihydrochloride

How Vanguard tests Trientine hydrochloride

Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, assay by potentiometric titration with a cupric ion-selective electrode, chromatographic purity by HPTLC and thin-layer chromatography, pH, loss on drying, and residue on ignition. Full testing to the USP Trientine Hydrochloride monograph is available and quoted.

What's reported

  • Purity, as percent of total peak area
  • Quantity, against the label claim
  • Identity, reported as match or no match against the reference standard
  • With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Trientine Hydrochloride (CAS 38260-01-4; free base CAS 112-24-3)
  • Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Trientine hydrochloride testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Trientine Hydrochloride monograph is available and quoted.

Why is trientine hard to measure with a standard UV detector?

Trientine is a straight-chain polyamine with no chromophore, so the lab uses a detection method suited to the compound.

Is trientine hygroscopic?

Yes. Trientine hydrochloride takes up water from air, which lowers the assay on an as-is basis. Samples should be kept tightly closed.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/71433

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.