Cisplatin

Cisplatin: platinum coordination complex (antineoplastic).

Cisplatin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Cisplatin: 2D structure drawn from the PubChem record (CID 5460033).

Compound data

CAS number

15663-27-1

Formula

Cl₂H₆N₂Pt

Molecular weight

300.05 g/mol

Type

Platinum coordination complex (antineoplastic)

Structure and names

Identity: Cisplatin

IUPAC name: azane;dichloroplatinum

How Vanguard tests Cisplatin

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by HPLC retention time and infrared spectroscopy, assay by HPLC, trichloroammineplatinate and transplatin by HPLC, a UV purity ratio, platinum content by ignition, and water. Full testing to the USP Cisplatin monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Cisplatin (CAS 15663-27-1)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Cisplatin testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cisplatin monograph is available and quoted.

Why does the cis versus trans form matter for cisplatin?

Transplatin has the same formula and mass as cisplatin but a different geometry. The monograph limits it with an HPLC procedure, since mass alone cannot tell the two apart.

Is cisplatin stable in solution?

In water without chloride it slowly swaps its chloride ligands for water, so solutions are prepared in sodium chloride. Samples usually arrive as yellow powder or as a solution in saline.

Can platinum content be measured?

Yes. Platinum can be measured by ICP-MS as a check on the assay, quoted with the test.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/5460033

Identity facts from the USP monograph header for this compound.

Order

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