Cladribine: purine nucleoside analog (antimetabolite).
Cladribine testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Cladribine: 2D structure drawn from the PubChem record (CID 20279).
4291-63-8
C10H12ClN5O3
285.69 g/mol
Purine nucleoside analog (antimetabolite)
Identity: Cladribine
IUPAC name: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, and optical rotation, water and residue on ignition. Full testing to the USP Cladribine monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cladribine monograph is available and quoted.
The bond between the base and the sugar is weak in acid, and cladribine breaks down to 2-chloroadenine. That product separates from cladribine in the HPLC purity profile.
Synthesis can form the alpha anomer as well as the intended beta form. The anomers have the same mass, so they are told apart by HPLC retention rather than LC-MS.
Usually as powder or as a dilute injectable solution. Give the labeled concentration so the result can be reported against it.
https://pubchem.ncbi.nlm.nih.gov/compound/20279
Identity facts from the USP monograph header for this compound.
Start an order online, or send the compound name and the tests you need for a quote.
