Clidinium bromide

Clidinium bromide: antimuscarinic (quaternary ammonium).

Clidinium bromide testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Clidinium bromide: 2D structure drawn from the PubChem record (CID 19004).

Compound data

CAS number

3485-62-9

Formula

C₂₂H₂₆BrNO₃

Molecular weight

432.35 g/mol

Type

Antimuscarinic (quaternary ammonium)

Structure and names

Identity: Clidinium bromide

IUPAC name: (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) 2-hydroxy-2,2-diphenylacetate bromide

How Vanguard tests Clidinium bromide

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, thin-layer chromatography and a bromide test, assay by potentiometric titration, related compounds by thin-layer chromatography, and loss on drying and residue on ignition. Full testing to the USP Clidinium Bromide monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Clidinium Bromide (CAS 3485-62-9)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Clidinium bromide testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Clidinium Bromide monograph is available and quoted.

Why does LC-MS show a different mass from the molecular weight?

Clidinium is a quaternary ammonium cation, so LC-MS detects the clidinium cation without its bromide counter-ion. The molecular weight on the page includes the bromide.

How does clidinium bromide degrade?

It is an ester of benzilic acid, and hydrolysis releases benzilic acid. That product separates from clidinium in the HPLC purity profile.

Why does the monograph use titration and TLC while the $250 test uses HPLC?

Titration measures total bromide salt and TLC gives a semi-quantitative impurity check. HPLC separates and measures clidinium and its related compounds in one run.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/19004

Identity facts from the USP monograph header for this compound.

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