Clobetasol propionate: corticosteroid (17-propionate ester).
Clobetasol propionate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Clobetasol propionate: 2D structure drawn from the PubChem record (CID 32798).
25122-46-7
C25H32ClFO5
466.97 g/mol
Corticosteroid (17-propionate ester)
Identity: Clobetasol propionate
IUPAC name: [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy, assay by HPLC, organic impurities by HPLC, and melting range, optical rotation, loss on drying and residue on ignition. Full testing to the USP Clobetasol Propionate monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Clobetasol Propionate monograph is available and quoted.
No. Clobetasol propionate is the 17-propionate ester of clobetasol and has a higher molecular weight. Hydrolysis of the ester gives free clobetasol, which shows as a separate peak in the HPLC purity profile.
Yes. Creams, ointments, lotions and shampoos are extracted to separate the steroid from the base before HPLC, and the result is reported as a percentage by weight.
It has been found as an undeclared ingredient in some skin creams. An HPLC screen with LC-MS confirmation can check a product for it.
https://pubchem.ncbi.nlm.nih.gov/compound/32798
Identity facts from the USP monograph header for this compound.
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