Cloprostenol sodium

Cloprostenol sodium: prostaglandin F2-alpha analog.

Cloprostenol sodium testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Cloprostenol sodium: 2D structure drawn from the PubChem record (CID 17756794).

Compound data

CAS number

55028-72-3

Formula

C₂₂H₂₈ClNaO₆

Molecular weight

446.90 g/mol

Type

Prostaglandin F2-alpha analog

Structure and names

Identity: Cloprostenol sodium

IUPAC name: sodium (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate

How Vanguard tests Cloprostenol sodium

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and a sodium test, assay by HPLC, organic impurities by HPLC, and water. Full testing to the USP Cloprostenol monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Cloprostenol
Cloprostenol Sodium (CAS 55028-72-3)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Cloprostenol sodium testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Cloprostenol monograph is available and quoted.

What is the difference between cloprostenol and d-cloprostenol?

Cloprostenol is a racemic mixture, while d-cloprostenol is the single active enantiomer. A standard HPLC purity test does not separate the two, so chiral testing is quoted separately.

What forms does cloprostenol arrive in?

Usually as an injectable solution at low concentration. Give the labeled concentration so the assay can be reported against it.

Does cloprostenol degrade?

Prostaglandin analogs are heat sensitive and can form epimers and dehydration products. These separate from cloprostenol in the HPLC purity profile, so samples should ship cold.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/17756794

Identity facts from the USP monograph header for this compound.

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