Crotamiton

Crotamiton: scabicide and antipruritic (N-ethyl crotonanilide).

Crotamiton testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Crotamiton: 2D structure drawn from the PubChem record (CID 2883).

Compound data

CAS number

483-63-6

Formula

C₁₃H₁₇NO

Molecular weight

203.28 g/mol

Type

Scabicide and antipruritic (N-ethyl crotonanilide)

Structure and names

Identity: Crotamiton

IUPAC name: N-ethyl-N-(2-methylphenyl)but-2-enamide

How Vanguard tests Crotamiton

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared and UV spectroscopy and a permanganate test, specific gravity, refractive index, residue on ignition, bound halogen, and assay by UV spectrophotometry. Full testing to the USP Crotamiton monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Crotamiton (CAS 483-63-6)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Crotamiton testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Crotamiton monograph is available and quoted.

Is crotamiton a single isomer?

No. Crotamiton is a mixture of the cis and trans (Z and E) isomers of the double bond, with trans as the main form. The two isomers can appear as separate peaks and are summed for the assay.

What form does crotamiton arrive in?

It is an oily liquid, and products are usually creams or lotions, which are extracted before HPLC.

Why add LC-MS identity when the monograph uses IR and UV?

IR and UV confirm the structure class, while LC-MS adds the molecular mass and separates crotamiton from other components of a cream.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/2883

Identity facts from the USP monograph header for this compound.

Order

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