Dantrolene sodium

Dantrolene sodium: skeletal muscle relaxant (hydantoin).

Dantrolene sodium testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

2D structure of Dantrolene sodium

Dantrolene sodium: 2D structure drawn from the PubChem record (CID 9568637).

Compound data

CAS number

24868-20-0

Formula

C14H9N4NaO5 · 3.5H2O

Molecular weight

399.29 g/mol

Type

Skeletal muscle relaxant (hydantoin)

Structure and names

Identity: Dantrolene sodium (hemiheptahydrate)

IUPAC name: disodium;bis(3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-2-oxo-4H-imidazol-5-olate);heptahydrate

How Vanguard tests Dantrolene sodium

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, HPLC retention time, a sodium test and a precipitation test, assay by HPLC with UV at 365 nm, related compound A and organic impurities by HPLC, and water determination. Full testing to the USP Dantrolene Sodium monograph is available and quoted.

What's reported

  • Purity, as percent of total peak area
  • Quantity, against the label claim
  • Identity, reported as match or no match against the reference standard
  • With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on testPrice
Identity and impurities
FTIR identity$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)$125
Chiral purity (where a chiral method exists; new methods quoted)$250
Water, solvents and salt form
Water content by Karl Fischer$60
Residual solvents$150
Counterions: chloride, acetate and TFA$70
Assay
Assay, % w/w (with raw powder purity; $250 together)+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead$150
Conformity: purity and quantity on more units from the same lot$100 per extra unit
Microbiology (injectables)
Endotoxin$210
Sterility or bioburden$150
Container closure integrity (CCI)$50
Screening
Fentanyl screen$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

  • Dantrolene Sodium (CAS 14663-23-1 hemiheptahydrate)
  • Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Dantrolene sodium testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and assay, with LC-MS to confirm identity. Full testing to the USP Dantrolene Sodium monograph is available and quoted.

Is the result reported as dantrolene sodium or dantrolene?

Dantrolene sodium is a hydrated salt, so the same mass contains less dantrolene than the free acid. Tell us the basis you need and the result is calculated from water content and the molecular weights.

Is dantrolene sensitive to light?

Yes. Dantrolene is an orange nitrofuran compound that degrades on light exposure. Ship samples in opaque containers.

What form does dantrolene sodium arrive in?

Usually as capsules or lyophilized powder for injection. It is poorly soluble in water, so the extraction uses an organic or basic solvent.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/9568637

Identity facts from the USP monograph header for this compound.

Order

Start an order online, or send the compound name and the tests you need for a quote.