Teriparatide

Teriparatide is the 1-34 fragment of human parathyroid hormone, a linear 34-residue peptide with a free N-terminus and a free C-terminal acid. A USP monograph exists for teriparatide.

Teriparatide testing at Vanguard Laboratory: purity, quantity and identity from $250 per vial, with results in 3 to 5 business days; sterility 14 days.

Teriparatide testing packages

Every package includes purity, quantity, identity and a solubility check. Raw powder purity is $200 for a 50 mg sample.

Level 1 Silver

$250

1 vial per sample

Level 2 Gold

$550

3 vials per sample

Level 3 Elite

$700

4 vials per sample

Tests for Teriparatide

Each test can be added to a package or ordered on its own. Results arrive in 3 to 5 business days.

Purity and quantity

Included in every package

How pure the Teriparatide is and how much is in the vial: purity in area percent, quantity in mg per vial against the label. Details

Conformity icon

Identity

Included in every package

Whether the sample contains Teriparatide, compared with a reference standard. Reported as match or no match. Details

LC-MS identity

Quoted

Whether the molecular mass matches Teriparatide, which helps catch look-alike products. Details

Heavy metals

$150

Lead, arsenic, cadmium, mercury and chromium. Included in Elite. Details

Counterion

$70

How much TFA, acetate or chloride the powder contains. Other salt forms are quoted. Details

Water content

Quoted

How much moisture the powder holds, used to work out the net content. Details

Fentanyl Screen

$50

Runs on the same vial. Included in Elite. Details

TFA Analysis

$50

Available at any level. Details

Vial seal integrity icon

Container Closure Integrity (CCI)

$50

Dye ingress, USP 1207. Available at any level. Details

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Conformity

$100 per extra vial

Vial-to-vial comparison within one lot. Details

Endotoxin

$210

Reported in EU per vial. Included in Gold and Elite. Details

Sterility or Bioburden

$150

Sterility for injectables: 1–10 unopened vials at the same sterility-test price. Bioburden for other forms. Included in Gold and Elite. Details

Residual Solvents

$150

Residual solvent panel. Details

API Purity

$200

Purity for API and raw powders. Details

$200 per vial

Purity and routine identity by retention time and UV spectrum against a reference standard, without quantity: no mg per vial, concentration or label-claim result. 1 vial; 3 to 5 business days. LC-MS is quoted separately. Details

BAC water icon

BAC Water

$200

Benzyl alcohol content and pH. Details

$360 per vial

Screen for semaglutide, tirzepatide and retatrutide without naming the expected peptide. Identity, amount and purity where reportable. Blind GLP-1 panel

Disulfide linkage

Quoted

Which cysteines are paired, by Orbitrap high-resolution mass spectrometry of the digested peptide.

IEX, HILIC and SEC purity

Quoted

Charge, polarity and size variants by ion-exchange, hydrophilic interaction and size-exclusion chromatography, alongside routine HPLC purity.

Conformity icon

Amino acid analysis

Quoted

Hydrolysis and amino acid analysis, to confirm composition and net peptide content.

Conformity icon

Chiral analysis

Quoted

D- and L-forms of the amino acids, to check for racemization.

Orders of ten or more samples are 10% off.

Compound data

Classification

linear 34-residue peptide, human parathyroid hormone (1-34)

Formula

C181H291N55O51S2

Molecular weight

4117.7 g/mol (PubChem rounds to 4118)
Monoisotopic 4115.13 Da

CAS number

52232-67-4

Sequence, structure and names

1 Ser · 2 Val · 3 Ser · 4 Glu · 5 Ile · 6 Gln · 7 Leu · 8 Met · 9 His · 10 Asn · 11 Leu · 12 Gly · 13 Lys · 14 His · 15 Leu · 16 Asn · 17 Ser · 18 Met · 19 Glu · 20 Arg · 21 Val · 22 Glu · 23 Trp · 24 Leu · 25 Arg · 26 Lys · 27 Lys · 28 Leu · 29 Gln · 30 Asp · 31 Val · 32 His · 33 Asn · 34 Phe

Modifications: none; free N-terminal amine and free C-terminal carboxylic acid. Two methionines (Met8 and Met18), no cysteine and no disulfide bond.

Other names: hPTH(1-34), rhPTH(1-34), parathyroid hormone (1-34) human

How Vanguard tests Teriparatide

Teriparatide runs on the lab’s peptide purity and quantity method: reversed-phase HPLC on a C18 column with a water and acetonitrile gradient containing 0.1% TFA, and UV detection at 214 to 220 nm. Purity is the main peak’s share of the total peak area, quantity is measured against a reference standard, and identity is confirmed by retention time and UV spectrum against the same standard. LC-MS confirmation of the intact mass is quoted separately.

A USP monograph exists for teriparatide. The method above is Vanguard’s own peptide method, not the monograph procedure.

What's reported

  • Purity, as percent of total peak area by HPLC-UV
  • Quantity, in mg per vial against the label claim
  • Identity, reported as match or no match against the reference standard
  • On request: intact mass by LC-MS, counterion (acetate or TFA) content, water content, endotoxin and sterility

Salts, forms and compendial references

  • Research teriparatide is usually a lyophilized acetate salt. Tell us whether the label states teriparatide or teriparatide acetate, so quantity is reported on the same basis.
  • A USP monograph exists for teriparatide. One page covers the peptide and its salt forms.

Sample amount and turnaround

Send 1 vial for Level 1 Silver, 3 vials for Level 2 Gold or 4 vials for Level 3 Elite; raw powder purity needs a 50 mg sample. Results arrive in 3 to 5 business days; sterility takes 14 days.

Questions about Teriparatide testing

Can you detect oxidized teriparatide?

Yes. Teriparatide has two methionines, at positions 8 and 18. Oxidized forms usually separate from the main peak by reversed-phase HPLC, so they lower the purity result, and LC-MS (quoted) can confirm the 16 Da mass increase that oxidation adds.

Can identity testing tell teriparatide from full-length PTH?

Yes. Full-length parathyroid hormone has 84 residues and a much higher mass, so it differs from teriparatide in retention time and, by LC-MS, in mass.

Does the acetate salt change the quantity result?

Quantity is reported as teriparatide peptide in mg per vial. The acetate or TFA counterion adds weight to the powder but not to the peptide result; the counterion test ($70) measures it if you need the salt content.

Order

Start an order online, or send the compound name and the tests you need for a quote.