Abacavir sulfate

Abacavir sulfate: nucleoside reverse transcriptase inhibitor (carbocyclic guanosine analog).

Abacavir sulfate testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Abacavir sulfate: 2D structure drawn from the PubChem record (CID 441300).

Compound data

CAS number

136470-78-5

Formula

C₁₄H₁₈N₆O

Molecular weight

286.33 g/mol

Type

Nucleoside reverse transcriptase inhibitor (carbocyclic guanosine analog)

Structure and names

Identity: Abacavir

IUPAC name: [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol

How Vanguard tests Abacavir sulfate

Method for the $250 identity, purity and quantity test: HPLC-UV purity and assay, LC-MS identity, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy, HPLC retention time and a chemical test, assay by HPLC, organic impurities by HPLC, and enantiomeric purity by chiral HPLC. Full testing to the USP Abacavir or Abacavir Sulfate monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Abacavir (CAS 136470-78-5)
Abacavir Sulfate (CAS 188062-50-2)
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Abacavir sulfate testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by HPLC-UV for purity and quantity and LC-MS for identity. Full testing to the USP Abacavir or Abacavir Sulfate monograph is available and quoted.

Does the standard test check enantiomeric purity?

No. The enantiomer of abacavir has the same mass and retention time on a standard column. Enantiomeric purity needs the chiral HPLC method in full USP monograph testing.

Is the result given as abacavir or abacavir sulfate?

Raw material is usually the sulfate salt, and abacavir is about 85 percent of the salt weight. The report states which basis the quantity is given on.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/441300

Identity facts from the USP monograph header for this compound.

Order

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