Amifostine: organic thiophosphate (aminothiol prodrug).
Amifostine testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.
Amifostine: 2D structure drawn from the PubChem record (CID 148139).
112901-68-5
C5H15N2O3PS · 3H2O
268.27 g/mol
Organic thiophosphate (aminothiol prodrug)
Identity: Amifostine trihydrate
IUPAC name: 2-(3-aminopropylamino)ethylsulfanylphosphonic acid;trihydrate
Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.
The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, organic impurities by HPLC, and pH and water. Full testing to the USP Amifostine monograph is available and quoted.
Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.
| Add-on test | Price |
|---|---|
| Identity and impurities | |
| FTIR identity | $90 |
| CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur) | $125 |
| Chiral purity (where a chiral method exists; new methods quoted) | $250 |
| Water, solvents and salt form | |
| Water content by Karl Fischer | $60 |
| Residual solvents | $150 |
| Counterions: chloride, acetate and TFA | $70 |
| Assay | |
| Assay, % w/w (with raw powder purity; $250 together) | +$50 |
| Metals and conformity | |
| Heavy metals: arsenic, cadmium, chromium, mercury and lead | $150 |
| Conformity: purity and quantity on more units from the same lot | $100 per extra unit |
| Microbiology (injectables) | |
| Endotoxin | $210 |
| Sterility or bioburden | $150 |
| Container closure integrity (CCI) | $50 |
| Screening | |
| Fentanyl screen | $50 |
10% off for 10 or more samples.
Need something else? Other tests are available on request.
Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.
No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Amifostine monograph is available and quoted.
The thiophosphate group hydrolyzes to the free thiol, which can then oxidize to its disulfide. Both are seen as separate peaks, so moisture and warmth during storage show up in the purity result.
The USP material is the trihydrate, and the water is a real part of its weight. Results are reported on the stated basis, so tell us if you need anhydrous values.
No. It has no aromatic ring, so the lab uses a detection method suited to the compound.
https://pubchem.ncbi.nlm.nih.gov/compound/148139
Identity facts from the USP monograph header for this compound.
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