Amikacin

Amikacin: aminoglycoside antibiotic.

Amikacin testing at Vanguard Laboratory: identity, purity and quantity $250 per sample, with results in 3 to 5 business days.

Structure

Amikacin: 2D structure drawn from the PubChem record (CID 37768).

Compound data

CAS number

37517-28-5

Formula

C₂₂H₄₃N₅O₁₃

Molecular weight

585.60 g/mol

Type

Aminoglycoside antibiotic

Structure and names

Identity: Amikacin

IUPAC name: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide

How Vanguard tests Amikacin

Method for the $250 identity, purity and quantity test: Chromatographic assay, with detection selected for the compound, against a reference standard, with results in 3 to 5 business days.

The USP monograph covers identity by infrared spectroscopy and HPLC retention time, assay by HPLC, and residue on ignition, optical rotation, pH and water. Full testing to the USP Amikacin monograph is available and quoted.

What's reported

Purity, as percent of total peak area
Quantity, against the label claim
Identity, reported as match or no match against the reference standard
With monograph testing (quoted): the monograph’s tests against its limits

Tests and prices

Purity and quantity

$250

Chromatographic purity and mg per unit by the method matched to the compound, identity against a reference standard. 1 unit.

Raw powder purity

$200

Chromatographic purity on bulk powder. 50 mg.

Add-on tests

Add-on test	Price
Identity and impurities
FTIR identity	$90
CHNS elemental analysis (carbon, hydrogen, nitrogen, sulfur)	$125
Chiral purity (where a chiral method exists; new methods quoted)	$250
Water, solvents and salt form
Water content by Karl Fischer	$60
Residual solvents	$150
Counterions: chloride, acetate and TFA	$70
Assay
Assay, % w/w (with raw powder purity; $250 together)	+$50
Metals and conformity
Heavy metals: arsenic, cadmium, chromium, mercury and lead	$150
Conformity: purity and quantity on more units from the same lot	$100 per extra unit
Microbiology (injectables)
Endotoxin	$210
Sterility or bioburden	$150
Container closure integrity (CCI)	$50
Screening
Fentanyl screen	$50

10% off for 10 or more samples.

Need something else? Other tests are available on request.

Sample amount and turnaround

Purity and quantity is $250 per sample (1 unit) and raw powder purity is $200 for 50 mg, with results in 3 to 5 business days. Send the material sealed and labeled, with the label claim and the form it contains.

Salts, forms and compendial references

Amikacin (CAS 37517-28-5)
Amikacin Sulfate
Tell us the salt or form the label states, so quantity is reported on the same basis.

Questions about Amikacin testing

Is the $250 test the same as USP monograph testing?

No. The $250 test covers identity, purity and quantity by a chromatographic assay, with detection selected for the compound. Full testing to the USP Amikacin monograph is available and quoted.

Why is amikacin hard to measure with a standard UV detector?

Aminoglycosides have no chromophore, so the lab uses a detection method suited to the compound.

Is amikacin base different from amikacin sulfate?

Yes. The sulfate salt carries a large share of sulfuric acid by weight, so the same powder reads very differently on a base or salt basis. Tell us which form you have.

Can kanamycin show up in amikacin?

Amikacin is made from kanamycin A, so kanamycin is a typical related substance. The two differ in mass and separate in the chromatographic test.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/37768

Identity facts from the USP monograph header for this compound.

Order

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